Principal/Senior System Engineer

System Requirements & Architecture Translate VOC/user needs into clear, verifiable system requirements. Define system boundaries, architecture, and interfaces across mechanical, electrical, controls, software, consumables and workflow. Lead system-level reviews (requirements/architecture/design), document trade-offs, and drive decision closure. Verification & Validation (V&V) Create and execute System Verification Plan: scope, strategy, test environments, and Pass/Fail criteria. Build and maintain requirements-to-verification traceability (e.g., traceability matrix, verification records). Produce controlled verification evidence packages (protocols/records/reports) and drive deviation/issue closure. Technical Evaluation & Risk Management Own technical evaluation for key design choices: feasibility, performance margins, reliability/serviceability considerations, and integration readiness. Identify system-level risks and drive mitigations/alternatives; enable high-quality gate decisions with evidence-based arguments. Automation Platform / Orchestration / AI-ready Support deploying an orchestration layer on equipment and/or workstations to enable more autonomous, integrated workflows. Drive “AI-ready” enablers (data readiness, integration hooks/APIs, workflow orchestration) to strengthen differentiation and win rates. Cross-functional Collaboration & Transfer Partner with R&D, Manufacturing, Quality, Regulatory, Supply Chain, Product/Commercial to align requirements, verification, and release readiness. Support tech transfer: system technical package, verification evidence, risk assessments/control inputs, and release decisions. Additional duties Perform other responsibilities as assigned to support the broader goals of the R&D and Innovation organizations. Join our winning team today. Together, we’ll accelerate the real-life impact of tomorrow’s science and technology. We partner with customers across the globe to help them solve their most complex challenges, architecting solutions that bring the power of science to life. For more information, visit www.danaher.com. Danaher is a leading global life sciences, biotechnology, and diagnostics innovator, helping to solve many of the world’s most important health challenges, ultimately improving quality of life for billions of people today, while setting the foundation for a healthier, more sustainable tomorrow. The Danaher ecosystem is made up of more than 15 businesses united by a shared commitment to innovate for tangible impact. Please read our Applicant Data Privacy Notice carefully here.